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Publication : Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior.

First Author  Bicks LK Year  2020
Journal  Nat Commun Volume  11
Issue  1 Pages  1003
PubMed ID  32081848 Mgi Jnum  J:358985
Mgi Id  MGI:6401575 Doi  10.1038/s41467-020-14740-z
Citation  Bicks LK, et al. (2020) Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior. Nat Commun 11(1):1003
abstractText  Social isolation during the juvenile critical window is detrimental to proper functioning of the prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, the specific circuits that undergo social experience-dependent maturation to regulate social behavior are poorly understood. We identify a specific activation pattern of parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior to an active bout, or a bout initiated by the focal mouse, but not during a passive bout when mice are explored by a stimulus mouse. Optogenetic and chemogenetic manipulation reveals that brief dmPFC-PVI activation triggers an active social approach to promote sociability. Juvenile social isolation decouples dmPFC-PVI activation from subsequent active social approach by freezing the functional maturation process of dmPFC-PVIs during the juvenile-to-adult transition. Chemogenetic activation of dmPFC-PVI activity in the adult animal mitigates juvenile isolation-induced social deficits. Therefore, social experience-dependent maturation of dmPFC-PVI is linked to long-term impacts on social behavior.
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