| First Author | Guo W | Year | 2017 |
| Journal | Neuron | Volume | 95 |
| Issue | 1 | Pages | 180-194.e5 |
| PubMed ID | 28625486 | Mgi Jnum | J:249923 |
| Mgi Id | MGI:6099298 | Doi | 10.1016/j.neuron.2017.05.019 |
| Citation | Guo W, et al. (2017) A Corticothalamic Circuit for Dynamic Switching between Feature Detection and Discrimination. Neuron 95(1):180-194.e5 |
| abstractText | Sensory processing must be sensitive enough to encode faint signals near the noise floor but selective enough to differentiate between similar stimuli. Here we describe a layer 6 corticothalamic (L6 CT) circuit in the mouse auditory forebrain that alternately biases sound processing toward hypersensitivity and improved behavioral sound detection or dampened excitability and enhanced sound discrimination. Optogenetic activation of L6 CT neurons could increase or decrease the gain and tuning precision in the thalamus and all layers of the cortical column, depending on the timing between L6 CT activation and sensory stimulation. The direction of neural and perceptual modulation - enhanced detection at the expense of discrimination or vice versa - arose from the interaction of L6 CT neurons and subnetworks of fast-spiking inhibitory neurons that reset the phase of low-frequency cortical rhythms. These findings suggest that L6 CT neurons contribute to the resolution of the competing demands of detection and discrimination. |
