| First Author | Miao Q | Year | 2016 |
| Journal | Cell Rep | Volume | 16 |
| Issue | 6 | Pages | 1677-1689 |
| PubMed ID | 27477277 | Mgi Jnum | J:238982 |
| Mgi Id | MGI:5824650 | Doi | 10.1016/j.celrep.2016.07.013 |
| Citation | Miao Q, et al. (2016) Selective Maturation of Temporal Dynamics of Intracortical Excitatory Transmission at the Critical Period Onset. Cell Rep 16(6):1677-89 |
| abstractText | Although the developmental maturation of cortical inhibitory synapses is known to be a critical factor in gating the onset of critical period (CP) for experience-dependent cortical plasticity, how synaptic transmission dynamics of other cortical synapses are regulated during the transition to CP remains unknown. Here, by systematically examining various intracortical synapses within layer 4 of the mouse visual cortex, we demonstrate that synaptic temporal dynamics of intracortical excitatory synapses on principal cells (PCs) and inhibitory parvalbumin- or somatostatin-expressing cells are selectively regulated before the CP onset, whereas those of intracortical inhibitory synapses and long-range thalamocortical excitatory synapses remain unchanged. This selective maturation of synaptic dynamics results from a ubiquitous reduction of presynaptic release and is dependent on visual experience. These findings provide an additional essential circuit mechanism for regulating CP timing in the developing visual cortex. |
