| First Author | Jung K | Year | 2023 |
| Journal | Nat Neurosci | Volume | 26 |
| Issue | 8 | Pages | 1379-1393 |
| PubMed ID | 37474640 | Mgi Jnum | J:359580 |
| Mgi Id | MGI:7788574 | Doi | 10.1038/s41593-023-01380-x |
| Citation | Jung K, et al. (2023) An adaptive behavioral control motif mediated by cortical axo-axonic inhibition. Nat Neurosci 26(8):1379-1393 |
| abstractText | Genetically defined subgroups of inhibitory interneurons are thought to play distinct roles in learning, but heterogeneity within these subgroups has limited our understanding of the scope and nature of their specific contributions. Here we reveal that the chandelier cell (ChC), an interneuron type that specializes in inhibiting the axon-initial segment (AIS) of pyramidal neurons, establishes cortical microcircuits for organizing neural coding through selective axo-axonic synaptic plasticity. We found that organized motor control is mediated by enhanced population coding of direction-tuned premotor neurons, with tuning refined through suppression of irrelevant neuronal activity. ChCs contribute to learning-dependent refinements by providing selective inhibitory control over individual pyramidal neurons rather than global suppression. Quantitative analysis of structural plasticity across axo-axonic synapses revealed that ChCs redistributed inhibitory weights to individual pyramidal neurons during learning. These results demonstrate an adaptive logic of the inhibitory circuit motif responsible for organizing distributed neural representations. Thus, ChCs permit efficient cortical computation in a targeted cell-specific manner. |
