| First Author | Sermet BS | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31860443 | Mgi Jnum | J:283665 |
| Mgi Id | MGI:6385837 | Doi | 10.7554/eLife.52665 |
| Citation | Sermet BS, et al. (2019) Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex. Elife 8:e52665 |
| abstractText | Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) somatosensory thalamic nucleus most densely innervates layer 4 (L4) barrels, whereas the higher-order posterior thalamic nucleus (medial part, POm) most densely innervates L1 and L5A. We optogenetically stimulated VPM or POm axons, and recorded evoked excitatory postsynaptic potentials (EPSPs) in different cell-types across cortical layers in wS1. We found that excitatory neurons and parvalbumin-expressing inhibitory neurons received the largest EPSPs, dominated by VPM input to L4 and POm input to L5A. In contrast, somatostatin-expressing inhibitory neurons received very little input from either pathway in any layer. Vasoactive intestinal peptide-expressing inhibitory neurons received an intermediate level of excitatory input with less apparent layer-specificity. Our data help understand how wS1 neocortical microcircuits might process and integrate sensory and higher-order inputs. |
