| First Author | Nestvogel DB | Year | 2022 |
| Journal | Neuron | Volume | 110 |
| Issue | 1 | Pages | 120-138.e4 |
| PubMed ID | 34687663 | Mgi Jnum | J:328606 |
| Mgi Id | MGI:6877234 | Doi | 10.1016/j.neuron.2021.10.005 |
| Citation | Nestvogel DB, et al. (2022) Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations. Neuron 110(1):120-138.e4 |
| abstractText | The brain exhibits distinct patterns of recurrent activity closely related to behavioral state. The neural mechanisms that underlie state-dependent activity in the awake animal are incompletely understood. Here, we demonstrate that two types of state-dependent activity, rapid arousal/movement-related signals and a 3-5 Hz alpha-like rhythm, in the primary visual cortex (V1) of mice strongly correlate with activity in the visual thalamus. Inactivation of V1 does not interrupt arousal/movement signals in most visual thalamic neurons, but it abolishes the 3-5 Hz oscillation. Silencing of the visual thalamus similarly eradicates the alpha-like rhythm and perturbs arousal/movement-related activation in V1. Intracellular recordings in thalamic neurons reveal the 3-5 Hz oscillation to be associated with rhythmic low-threshold Ca(2+) spikes. Our results indicate that thalamocortical interactions through ionotropic signaling, together with cell-intrinsic properties of thalamocortical cells, play a crucial role in shaping state-dependent activity in V1 of the awake animal. |
