| First Author | Ring NAR | Year | 2023 |
| Journal | Dev Cell | Volume | 58 |
| Issue | 11 | Pages | 981-992.e6 |
| PubMed ID | 37098351 | Mgi Jnum | J:359737 |
| Mgi Id | MGI:7489492 | Doi | 10.1016/j.devcel.2023.04.001 |
| Citation | Ring NAR, et al. (2023) The p-rpS6-zone delineates wounding responses and the healing process. Dev Cell 58(11):981-992.e6 |
| abstractText | The spatial boundaries of tissue response to wounding are unknown. Here, we show that in mammals, the ribosomal protein S6 (rpS6) is phosphorylated in response to skin injury, forming a zone of activation surrounding the region of the initial insult. This p-rpS6-zone forms within minutes after wounding and is present until healing is complete. The zone is a robust marker of healing as it encapsulates features of the healing process, including proliferation, growth, cellular senescence, and angiogenesis. A mouse model that is unable to phosphorylate rpS6 shows an initial acceleration of wound closure, but results in impaired healing, identifying p-rpS6 as a modulator but not a driver of healing. Finally, the p-rpS6-zone accurately reports on the status of dermal vasculature and the effectiveness of healing, visually dividing an otherwise homogeneous tissue into regions with distinct properties. |
