| First Author | Zhang YW | Year | 2007 |
| Journal | Oncogene | Volume | 26 |
| Issue | 2 | Pages | 269-76 |
| PubMed ID | 16819504 | Mgi Jnum | J:117840 |
| Mgi Id | MGI:3697792 | Doi | 10.1038/sj.onc.1209790 |
| Citation | Zhang YW, et al. (2007) Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26(2):269-76 |
| abstractText | Mitogen-inducible gene 6 (MIG-6) is located in human chromosome 1p36, a locus frequently associated with human lung cancer. MIG-6 is a negative regulator of epidermal growth factor (EGF) signaling, and we show that Mig-6 - like EGF - is induced by hepatocyte growth factor/scatter factor (HGF/SF) in human lung cancer cell lines. Frequently, the receptors for both factors, EGFR and Met, are expressed in same lung cancer cell line, and MIG-6 is induced by both factors in a mitogen-activated protein kinase-dependent fashion. However, not all tumor lines express MIG-6 in response to either EGF or HGF/SF. In these cases, we find missense and nonsense mutations in the MIG-6 coding region, as well as evidence for MIG-6 transcriptional silencing. Moreover, germline disruption of Mig-6 in mice leads to the development of animals with epithelial hyperplasia, adenoma, and adenocarcinoma in organs like the lung, gallbladder, and bile duct. These data suggests that MIG-6 is a tumor-suppressor gene and is therefore a candidate gene for the frequent 1p36 genetic alterations found in lung cancer. |
