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Publication : Sexual dimorphism in the vasopressin system: lack of an altered behavioral phenotype in female V1a receptor knockout mice.

First Author  Bielsky IF Year  2005
Journal  Behav Brain Res Volume  164
Issue  1 Pages  132-6
PubMed ID  16046007 Mgi Jnum  J:101024
Mgi Id  MGI:3590390 Doi  10.1016/j.bbr.2005.06.005
Citation  Bielsky IF, et al. (2005) Sexual dimorphism in the vasopressin system: lack of an altered behavioral phenotype in female V1a receptor knockout mice. Behav Brain Res 164(1):132-6
abstractText  Previous findings with an AVP V1a receptor knockout mouse (V1aRKO) demonstrate a significant role for this receptor in anxiety-like behavior in males. Here we report the lack of anxiety-like effects of the null mutation in female mice. V1aRKO females performed normally on all tests for anxiety-like behavior. This sex difference may be due to the sexual dimorphism in the extra-hypothalamic vasopressin system, with males having significantly more vasopressin fibers in this system.
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