First Author | Bielsky IF | Year | 2005 |
Journal | Behav Brain Res | Volume | 164 |
Issue | 1 | Pages | 132-6 |
PubMed ID | 16046007 | Mgi Jnum | J:101024 |
Mgi Id | MGI:3590390 | Doi | 10.1016/j.bbr.2005.06.005 |
Citation | Bielsky IF, et al. (2005) Sexual dimorphism in the vasopressin system: lack of an altered behavioral phenotype in female V1a receptor knockout mice. Behav Brain Res 164(1):132-6 |
abstractText | Previous findings with an AVP V1a receptor knockout mouse (V1aRKO) demonstrate a significant role for this receptor in anxiety-like behavior in males. Here we report the lack of anxiety-like effects of the null mutation in female mice. V1aRKO females performed normally on all tests for anxiety-like behavior. This sex difference may be due to the sexual dimorphism in the extra-hypothalamic vasopressin system, with males having significantly more vasopressin fibers in this system. |