| First Author | Bielsky IF | Year | 2005 |
| Journal | Neuron | Volume | 47 |
| Issue | 4 | Pages | 503-13 |
| PubMed ID | 16102534 | Mgi Jnum | J:123046 |
| Mgi Id | MGI:3716276 | Doi | 10.1016/j.neuron.2005.06.031 |
| Citation | Bielsky IF, et al. (2005) The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Neuron 47(4):503-13 |
| abstractText | Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior. |
