| First Author | Foster WH | Year | 2013 |
| Journal | Dev Dyn | Volume | 242 |
| Issue | 9 | Pages | 1101-9 |
| PubMed ID | 23723158 | Mgi Jnum | J:199575 |
| Mgi Id | MGI:5503245 | Doi | 10.1002/dvdy.23990 |
| Citation | Foster WH, et al. (2013) Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn 242(9):1101-9 |
| abstractText | Background: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage. However, its in vivo function is unknown. Results: Here we show that ppm1g expression is highly enriched in the central nervous system during mouse and zebrafish development. ppm1g(-/-) mice were embryonic lethal with incomplete penetrance after E12.5. Rostral defects, including neural tube and craniofacial defects were observed in ppm1g(-/-) embryos associated with increased cell death in the neural epithelium. In zebrafish, loss of ppm1g also led to neural defects with aberrant neural marker gene expression. Primary fibroblasts from ppm1g(-/-) embryos failed to grow without immortalization while immortalized ppm1g(-/-) fibroblasts had increased cell death upon oxidative and genotoxic stress when compared to wild type fibroblasts. Conclusions: Our in vivo and in vitro studies revealed a critical role for PPM1G in normal development and cell survival. Developmental Dynamics 242:1101-1109, 2013. (c) 2013 Wiley Periodicals, Inc. |
