| First Author | Pruvost M | Year | 2017 |
| Journal | Glia | Volume | 65 |
| Issue | 12 | Pages | 1961-1975 |
| PubMed ID | 28850711 | Mgi Jnum | J:253082 |
| Mgi Id | MGI:6098996 | Doi | 10.1002/glia.23207 |
| Citation | Pruvost M, et al. (2017) ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function. Glia 65(12):1961-1975 |
| abstractText | Myelination is a late developmental process regulated by a set of inhibitory and stimulatory factors, including extracellular matrix components. Accordingly, chondroitin sulfate proteoglycans (CSPGs) act as negative regulators of myelination processes. A disintegrin and metalloproteinase with thrombospondin motifs type 4 (ADAMTS-4) is an extracellular protease capable of degrading CSPGs. Although exogenous ADAMTS-4 has been proven to be beneficial in several models of central nervous system (CNS) injuries, the physiological functions of endogenous ADAMTS-4 remain poorly understood. We first used Adamts4/LacZ reporter mice to reveal that ADAMTS-4 is strongly expressed in the CNS, especially in the white matter, with a cellular profile restricted to mature oligodendrocytes. Interestingly, we evidenced an abnormal myelination in Adamts4(-/-) mice, characterized by a higher diameter of myelinated axons with a shifting g-ratio. Accordingly, lack of ADAMTS-4 is accompanied by motor deficits and disturbed nervous electrical activity. In conclusion, we demonstrate that ADAMTS-4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities. |
