| First Author | Shinnakasu R | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 7 | Pages | 861-9 |
| PubMed ID | 27158841 | Mgi Jnum | J:260241 |
| Mgi Id | MGI:6140782 | Doi | 10.1038/ni.3460 |
| Citation | Shinnakasu R, et al. (2016) Regulated selection of germinal-center cells into the memory B cell compartment. Nat Immunol 17(7):861-9 |
| abstractText | Despite the importance of memory B cells in protection from reinfection, how such memory cells are selected and generated during germinal-center (GC) reactions remains unclear. We found here that light-zone (LZ) GC B cells with B cell antigen receptors (BCRs) of lower affinity were prone to enter the memory B cell pool. Mechanistically, cells in this memory-prone fraction had higher expression of the transcriptional repressor Bach2 than that of their counterparts with BCRs of higher affinity. Haploinsufficiency of Bach2 resulted in reduced generation of memory B cells, independently of suppression of the gene encoding the transcription factor Blimp-1. Bach2 expression in GC cells was inversely correlated with the strength of help provided by T cells. Thus, we propose an instructive model in which weak help from T cells maintains relatively high expression of Bach2, which predisposes GC cells to enter the memory pool. |
