| Primary Identifier | MGI:3605892 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Smarca4 |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Aortic Valve Disease J:226941 in mice homozygous for Smarca4tm1.2Pcn and heterozygous for either Nfatc1tm1(cre)Bz or Nfatc1tm1.1(cre)Bz. |
| molecularNote | A single loxP site was inserted upstream of exon 18 and a floxed hygromycin resistance cassette was inserted downstream of exon 19. The hygromycin resistance cassette was selectively excised from correctly targeted ES cells by transient transfection with a cre-expression vector. Exons 18 and 19, encoding part of the ATPase-helicase motifs, were thus flanked by loxP sites in the resulting ES cells. |
