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Allele : Cpt1a<tm1Pwo> carnitine palmitoyltransferase 1a, liver; targeted mutation 1, Philip A Wood

Primary Identifier	MGI:3606251	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Cpt1a
Transmission	Germline	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

A targeting construct was designed to replace exons 11-18 with a neomycin resistance gene in the reverse orientation to transcription. FISH confirmed correct targeting of the locus.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Cpt-1a<tm1Uab>,
Cpt-1a<tm1Uab>

earliestPublication:
Nyman LR, et al. (2005) Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse. Mol Genet Metab 86(1-2):179-87

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

6 Publication categories

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