| Primary Identifier | MGI:3608909 | Allele Type | Spontaneous |
| Gene | Del(1)1Brk | Inheritance Mode | Recessive |
| Strain of Origin | CBA/J | Is Recombinase | false |
| Is Wild Type | false |
| description | A transgene comprising the bacterial artificial chromosome (BAC) RPCI-22 11D19, containing Steap3 and C1ql2, restored normal hemoglobin levels in mice homozygous for the deletion. Three overlapping BAC transgenes encompassing the rest of the deletion region failed to affect the phenotype, as did a truncated transgene derived from RPCI-22 11D19 that contained only C2ql2. J:103440 The anemia phenotype of the homozygous mice is recapitulated by a targeted mutation of Steap3, which also fails to complement the deletion in trans. The phenotype of the complex heterozygote is described above. J:103440 |
| molecularNote | This spontaneous deletion comprises approximately 400 kb and removes all or part of six genes at about 63.1-64.1 cM on Chr 1. |
