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Allele : Pdpk1<tm1Bcol> 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Barry J Collins

Primary Identifier  MGI:3608995 Allele Type  Targeted
Attribute String  Hypomorph, Inserted expressed sequence Gene  Pdpk1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting construct was designed to replace arginine with methionine at position 131 (R131M) in exon 4, disrupting the phopshate groove but retaining catalytic activity and integrity of the hydrophobic groove. Protein was expressed normally in mutant ES cells.
  • mutations:
  • Disruption caused by insertion of vector
  • synonyms:
  • PDK1<131M>,
  • PDK1<131M>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories