| Primary Identifier | MGI:3608968 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Modified isoform(s) | Gene | Psen1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A targeting construct was designed to insert a P264L mutation into exon 8. Northern blot demonstrated mRNA levels were comparable in mutants and wild-type mice. Western blot indicated that despite normal mRNA expression, expression of N- and C-terminal fragments was reduced by about 50%. |
