| First Author | Takayanagi Y | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 9 | Pages | 951-5 |
| PubMed ID | 18520999 | Mgi Jnum | J:137036 |
| Mgi Id | MGI:3797674 | Doi | 10.1097/WNR.0b013e3283021ca9 |
| Citation | Takayanagi Y, et al. (2008) Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport 19(9):951-5 |
| abstractText | The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr-/- mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis. |
