| First Author | Li F | Year | 2013 |
| Journal | Nat Med | Volume | 19 |
| Issue | 4 | Pages | 418-20 |
| PubMed ID | 23475203 | Mgi Jnum | J:283481 |
| Mgi Id | MGI:6211418 | Doi | 10.1038/nm.3104 |
| Citation | Li F, et al. (2013) Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med 19(4):418-20 |
| abstractText | Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that co-treatment with RIF and INH causes accumulation of the endogenous hepatotoxin protoporphyrin IX in the liver through PXR-mediated alteration of the heme biosynthesis pathway. These results provide insight into the mechanism of liver injury induced by co-treatment with these compounds and may lead to their safer use in the clinic. |
