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Allele : Cbl<tm2Wlan> Casitas B-lineage lymphoma; targeted mutation 2, Wallace Y Langdon

Primary Identifier	MGI:3610727	Allele Type	Targeted
Attribute String	Inserted expressed sequence	Gene	Cbl
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

A point mutation resulted in a cysteine to alanine substitution at position 379 (C379A). Western blot showed that protein levels in thymocytes were not affected by the mutation.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
A,
c-Cbl(C379A),
c-Cbl<A>,
A,
c-Cbl<A>,
c-Cbl(C379A)

earliestPublication:
Thien CB, et al. (2005) Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J 24(21):3807-19

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

12 Publication categories

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