| Primary Identifier | MGI:3610508 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence, Null/knockout | Gene | Afp |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Cebpa cDNA and a neomycin resistance gene in opposite orientation replaced exon 1 of the alpha fetoprotein locus. Quantitative RT-PCR of fetal livers demonstrated that mutants had a higher level of Cebpa mRNA than wild-type livers. It was undetermined whether those higher levels were due to expression of the knock-in gene alone or due to a combination of the knock-in gene plus elevated expression of the endogenous gene. |
