| First Author | Heller E | Year | 1984 |
| Journal | Exp Hematol | Volume | 12 |
| Issue | 8 | Pages | 645-9 |
| PubMed ID | 6489477 | Mgi Jnum | J:7613 |
| Mgi Id | MGI:56082 | Citation | Heller E, et al. (1984) Chromosomal assignment of two murine genes controlling susceptibility to spleen focus formation by Rauscher leukemia virus. Exp Hematol 12(8):645-9 |
| abstractText | Two murine genes affecting susceptibility to spleen focus formation by RLV were assigned to chromosomes. The gene Rv-2, which controls susceptibility to spleen focus formation, was assigned to chromosome 9, and closely linked to the Fv-2 gene, by using the two congenic strains B10.C(47N)/Sn and B6.C-H-7b/By. These congenic strains, which were previously shown to carry the BALB/cJ allele for susceptibility to FLV on chromosome 9, were also susceptible to RLV, as determined by number of foci on the spleens of infected mice. A second gene which contributes to the susceptibility to spleen focus formation by RLV was assigned to the X chromosome because hemizygous male offspring of crosses between resistant-strain females and susceptible-strain males (C57BL/6J X CBA/Lac) showed significantly lower numbers of foci/spleen than the female littermates and than the offsprings, males and females, of the reciprocal cross (CBA/Lac X C57BL/6J). We suggest this gene be called Rv-3. |
