Primary Identifier | MGI:3611748 | Allele Type | Targeted |
Attribute String | Conditional ready, Hypomorph | Gene | Keap1 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was created in which exons 4-6 were floxed with loxP sites. This region encodes the double glycine repeat domain. Excision of these exons is predicted to result in generation of a truncated form incapable of repressing Nfe2l2 activity. This allele has reduced expression of the protein and is hypomorphic. |