| First Author | Smid JK | Year | 2015 |
| Journal | Endocrinology | Volume | 156 |
| Issue | 3 | Pages | 824-36 |
| PubMed ID | 25485969 | Mgi Jnum | J:221511 |
| Mgi Id | MGI:5640902 | Doi | 10.1210/en.2014-1637 |
| Citation | Smid JK, et al. (2015) Periostin induces pancreatic regeneration. Endocrinology 156(3):824-36 |
| abstractText | We found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes. Importantly, after partial pancreatectomy, Postn-deficient mice exhibit impaired mesenchymal formation and reduced regeneration specifically within the pancreatic beta-cell compartment. Furthermore, Postn-deficient mice demonstrate an increased sensitivity to streptozotocin. Notably, injection of Postn directly into the pancreas stimulated proliferation of vimentin-expressing cells within 24 hours, and by 3 days, a mesenchymal stroma was present containing proliferating duct-like cells expressing the progenitor markers Ngn3 and Pdx1. Intraperitoneal injection of Postn resulted in increased numbers of islets and long-term glucoregulatory benefits with no adverse effects found in other tissues. Delivery of Postn throughout the pancreas via the common bile duct resulted in increased numbers of small insulin-expressing clusters and a significant improvement in glucose tolerance. Therefore, Postn is novel molecule capable of potentiating pancreatic beta-cell regeneration. |
