| Primary Identifier | MGI:3612443 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(Gnrh1-cre)1Rsp |
| Strain of Origin | Not Specified | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | The mouse gonadotropin-releasing hormone promoter was used to drive the expression of improved cre (icre). The icre was assembled from oligonucleotides to introduce silent base mutations corresponding to human codon-usage preferences, minimize CpG content, eliminate putative cryptic splice sites and alter the stop codon. Cre activity was detected in 97% of Gnrh immunopositive neurons and in a second population of cells, mainly the limbic system neurons. Four lines exhibiting high expression and three with low expression were obtained. This is a representative from those lines. |
