Primary Identifier | MGI:3616018 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Hoxd |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This allele was created in the same ES cells used to create Hoxdtm18.1(Hoxd11)Ddu and thus has a Hoxd11/lacZ/loxP site located 5' of Hoxd13. A lacZ reporter sequence followed by a PGKneo selection cassette was inserted into exon 2 of Hoxd1. In vitro cre expression removed the entire Hoxd cluster replacing it with a Hoxd11/lacZ fusion gene. |