| Primary Identifier | MGI:3614966 | Allele Type | Targeted |
| Gene | Del(11Irf1-D11Mit23)1Rub | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| description | Mice homozygous for this deletion and hemizygous for the human YAC transgene Tg(A94G6)1Rub were indistinguishable from wild-type control animals for body weight, liver size, heart size, life span, plasma and hepatic triglyceride levels, and hepatic VLDL triglyceride secretion. As SLC22A5 is the only entire gene present in this transgene, but not in others that failed to complement the homozygous deletion phenotype, the phenotype of Del11Irf1-Csf2)1Rub homozygotes is attributed to loss of this gene. |
| molecularNote | This engineered 450 kb deletion encompasses exon 10 of Irf1, all of Csf2 and approximately 2 kb of downstream DNA, and 9 known or putative genes between these loci on mouse Chr 11 and/or the homologous region of human Chr 5q31. |
