| First Author | Barak Y | Year | 2006 |
| Journal | MGI Direct Data Submission | Mgi Jnum | J:105694 |
| Mgi Id | MGI:3616349 | Citation | Barak Y (2006) Creation of the allele Ppardtm1.2Rev. MGI Direct Data Submission |
| abstractText | Heterozygous mice are viable and fertile. All homozygous mice die in utero. Macrophages homozygous for this mutation have no transcriptional response to very low-density lipoprotein treatment. No evaluation of lacZ expression is published. Homozygous mice have a similar, albeit earlier, embryonic phenotype as the exon 4 deleted mutants described in other publications (Barak PNAS 2002 99:303-8, Chawla PNAS 2003 100:1268-73, and Lee Science 2003 302:453-7). Heterozygous mice or homozygous embryo-derived cells may be useful in studies of embryo development, adipocyte physiology, fat metabolism and storage, inflammation, and cancer. |
