| Primary Identifier | MGI:3617784 | Allele Type | Targeted |
| Gene | Plin2 | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Homologous recombination was used to replace exons 2 and 3 with a beta geo cassette. Northern and Western blot analyses failed to detect transcript and protein, respectively, in mutants. However, a subsequent study has identified a truncated translation product beginning at an alternative start site in exon 5 by using a C-terminal specific antibody. The truncated protein is detectable in cytoplasmic lipid droplets of the secretory epithelial cells in mammary glands after parturition. |
