| First Author | Tian JZ | Year | 2021 |
| Journal | Sci Rep | Volume | 11 |
| Issue | 1 | Pages | 12614 |
| PubMed ID | 34131249 | Mgi Jnum | J:314227 |
| Mgi Id | MGI:6814269 | Doi | 10.1038/s41598-021-92075-5 |
| Citation | Tian JZ, et al. (2021) SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury. Sci Rep 11(1):12614 |
| abstractText | In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the adult mouse pancreas. Genetic lineage tracing shows that during pancreatic development, descendants of SETD4(+) cells make up over 70% of pancreatic cells and then contribute to each pancreatic lineage during pancreatic homeostasis. SETD4(+) cells generate newborn acinar cells in response to cerulein-induced pancreatitis in acinar compartments. Ablation of SETD4(+) cells compromises regeneration of acinar cells, in contrast to controls. Our findings provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4(+) cell population. Potential applications may act to preserve pancreatic function in case of pancreatic disease and/or damage. |
