| Primary Identifier | MGI:3617002 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Manba |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Disruption of out-of-frame exon 5 with a neomycin cassette via homologous recombination resulted in the splicing of exon 4 to exon 6. This resulted in the introduction of a premature translational stop codon. Homozygous mutant mice had no detectable beta-mannosidase activity in any tissue, and heterozygotes had apporoximately half the enzyme activity of wild-type. Alpha-mannosidase activity was increased in the mutants compared to wild-type, especially at older ages. |
