| First Author | Murashima-Suginami A | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 359 |
| Issue | 3 | Pages | 549-55 |
| PubMed ID | 17555714 | Mgi Jnum | J:122387 |
| Mgi Id | MGI:3714221 | Doi | 10.1016/j.bbrc.2007.05.148 |
| Citation | Murashima-Suginami A, et al. (2007) Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun 359(3):549-55 |
| abstractText | The term 'supernumerary teeth' describes production of more than the normal number of teeth in the primary or permanent dentitions. Their aetiology is not understood. Uterine sensitization associated gene-1 (USAG-1) is a BMP antagonist that plays important roles in the local regulation of BMP signaling by binding and neutralizing BMP activities [M. Yanagita, BMP antagonists: their roles in development and involvement in pathophysiology, Cytokine Growth Factor Rev. 16 (2005) 309-317], and also serves as a modulator of Wnt signaling [N. Itasaki, C.M. Jones, S. Mercurio, A. Rowe, P.M. Domingos, J.C. Smith, R. Krumlauf, Wise, a context-dependent activator and inhibitor of Wnt signaling, Development 130 (2003) 4295-4305]. We report here that USAG-1 deficient mice have supernumerary teeth. The supernumerary maxillary incisor appears to form as a result of the successive development of the rudimentary upper incisor tooth. We confirmed that the USAG-1 expression is localized to the epithelium and mesenchyme of the rudimentary maxillary incisor tooth organ formation. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. Based upon these results, we conclude that USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis. |
