| First Author | Jacoby RF | Year | 1994 |
| Journal | Genomics | Volume | 22 |
| Issue | 2 | Pages | 381-7 |
| PubMed ID | 7806225 | Mgi Jnum | J:19675 |
| Mgi Id | MGI:67815 | Doi | 10.1006/geno.1994.1399 |
| Citation | Jacoby RF, et al. (1994) Genetic analysis of colon cancer susceptibility in mice. Genomics 22(2):381-7 |
| abstractText | Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q. |
