| Primary Identifier | MGI:3618122 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ly9 |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| description | Despite a significant defect in early T cell activation and a slight but significant defect in the Th2 response of CD4+ T cells, homozygous mutant mice mount appropriate T and B cell responses to lymphocytic choriomeningitis virus, their NKT cell development is normal, and mutant macrophages exhibit no defects in cytokine production or bacterial killing. |
| molecularNote | A 3' part of exon 2 and all of intron 2 have been replaced by a neomycin resistance gene. Western blot analysis of thymocytes and FACS analysis of splenocytes from homozygous mutant mice using rabbit antisera against the extracellular domain detected no LY9 (CD229) protein on these cells. |
