| Primary Identifier | MGI:3619918 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Thy1-Ntrk2/EGFP)817Cnl |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene consists of the Thy1 promoter followed by a loxP flanked stop signal and a truncated form of the murine Ntrk2 gene fused to EGFP. The truncated cDNA for Ntrk2 includes the region encoding amino acids 1-477 plus 74 bp of the 5' UTR. Cre mediated recombination removes the stop and allows expression of the fusion protein which functions as a dominant negative receptor. Seven founders were created however data for line 817 only were shown. |
