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Allele : Braf<tm1Sva> Braf transforming gene; targeted mutation 1, Alcino J Silva

Primary Identifier  MGI:3620008 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Braf
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting construct was designed to flank exon 12 (exon 9 according to nomenclature in J:29234) with loxP sites. This exon is the first to encode the kinase domain. Its excision would result in a frame shift in the ORF, resulting in a null mutation. Western blot confirmed that insertion of the loxP sites did not affect protein expression levels.
  • mutations:
  • Insertion
  • synonyms:
  • B-raf<f>,
  • B-raf<f>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

25 Publication categories