| Primary Identifier | MGI:3620562 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Adam19 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A PGK-neo replaced exons 10-12. Exon 11 contains the active site of the metalloprotease domain. The construct generated a frame shift, thereby allowing mutants to express only an N-terminal truncated protein. RT-PCR failed to detect wild-type transcript in mutants. An alternatively spliced isoform lacking the metalloprotease and disintegrin domains also failed to be detected. |
