| First Author | Montecino-Rodriguez E | Year | 2016 |
| Journal | Immunity | Volume | 45 |
| Issue | 3 | Pages | 527-539 |
| PubMed ID | 27566938 | Mgi Jnum | J:259907 |
| Mgi Id | MGI:6141775 | Doi | 10.1016/j.immuni.2016.07.012 |
| Citation | Montecino-Rodriguez E, et al. (2016) Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development. Immunity 45(3):527-539 |
| abstractText | B cell development is often depicted as a linear process initiating in the fetus and continuing postnatally. Using a PU.1 hypomorphic mouse model, we found that B-1 and B-2 lymphopoiesis occurred in distinct fetal and adult waves differentially dependent on the Sfpi1 14 kB upstream regulatory element. The initial wave of fetal B-1 development was absent in PU.1 hypomorphic mice, while subsequent fetal and adult waves emerged. In contrast, B-2 lymphopoiesis occurred in distinct fetal and adult waves. Whole-transcriptome profiling of fetal and adult B cell progenitors supported the existence of three waves of B-1 and two waves of B-2 development and revealed that the network of transcription factors governing B lineage specification and commitment was highly divergent between B-1 and B-2 progenitors. These findings support the view that the B-1 and B-2 lineages are distinct and provide a genetic basis for layering of immune system development. |
