| Primary Identifier | MGI:3619458 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(IGL-MYC)3Hm |
| Inheritance Mode | Dominant | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A mutant human MYC gene isolated from a Burkitt lymphoma cell line and characterized by a shift in promoter use from P2 to P1 is fused to a 12 kb human genomic DNA segment containing the intronic enhancer and other functional elements of the IGL locus control region. RT-PCR analysis of various tissues of young, lymphoma-free transgenic mice detects high levels of MYC mRNA in lymphoid tissues, but no or very low levels elsewhere. Immunoblot analysis with human MYC-specific antibodies consistently detects low levels of the protein in spleens of transgenic mice. |
