| Primary Identifier | MGI:3620627 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Lmna |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A targeting vector was designed to delete the last 150 nucleotides of exon 11 and all of intron 11. The deletion created an in-frame fusion between codon 608 in exon 11 and codon 659 in exon 12. A floxed neo included in the vector was removed via cre-mediated recombination. Northern and Western blot demonstrated that no lamin A was produced. Lamin C was produced at wild-type levels. |
