| First Author | Jin M | Year | 2006 |
| Journal | Brain Res | Volume | 1075 |
| Issue | 1 | Pages | 117-21 |
| PubMed ID | 16469302 | Mgi Jnum | J:106948 |
| Mgi Id | MGI:3619806 | Doi | 10.1016/j.brainres.2005.12.099 |
| Citation | Jin M, et al. (2006) Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases. Brain Res 1075(1):117-21 |
| abstractText | Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. In this study, we generated latexin-deficient mice that exhibited increased tail-flick latency compared to wild-type animals upon noxious heat stimulation. The reduced pain sensitivity in the mutants was rescued by the systemic administration of a plant carboxypeptidase inhibitor that inhibits the A/B subfamily of metallocarboxypeptidases. These findings suggest that latexin is involved in the transmission of pain. |
