Primary Identifier | MGI:3622811 | Allele Type | QTL |
Gene | Gipc3 | Inheritance Mode | Recessive |
Strain of Origin | Black Swiss | Is Recombinase | false |
Is Wild Type | false |
description | Animals homozygous for Black Swiss-derived alleles at Ahl5 and Ahl6 exhibit significantly increased hearing threshold. |
molecularNote | A G to A (G343A) nucleotide substitution in exon 2 of the Gipc3 gene that results in the amino acid substitution of glycine for arginine at position 115 within the PDZ domain (aa107-174). This allele confers increased hearing threshold compared to CAST/EiJ. |