| Primary Identifier | MGI:3623135 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Trpc6 |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| description | The reported phenotypes did not differ among mice from backcross generations N1 through N10 to C57BL/6J. Trpc3 mRNA is elevated 3- to 5-fold in thoracic aorta and 2-fold in cerebral arteries of mutant mice compared to wild-type littermates, and Trpc7 mRNA is increased 2-fold in mutant cerebral arteries; levels of other Trpc mRNAs do not differ between mutant and control vessels. |
| molecularNote | A neomycin resistance cassette replaces exon 7, which encodes amino acids 584-670 comprising transmembrane domains 4 and 5 and a small part of the pore domain. Segments of mRNA upstream or downstream of the deletion cannot be amplified by RT-PCR from total lung RNA of homozygous mutant mice. |
