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Publication : Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function.

First Author  Clapcote SJ Year  2006
Journal  Genetics Volume  173
Issue  4 Pages  2407-10
PubMed ID  16751659 Mgi Jnum  J:111837
Mgi Id  MGI:3654952 Doi  10.1534/genetics.106.060749
Citation  Clapcote SJ, et al. (2006) Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10
abstractText  We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.
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