| First Author | Fehniger TA | Year | 2001 |
| Journal | Blood Cells Mol Dis | Volume | 27 |
| Issue | 1 | Pages | 223-30 |
| PubMed ID | 11358383 | Mgi Jnum | J:69192 |
| Mgi Id | MGI:1934280 | Doi | 10.1006/bcmd.2001.0379 |
| Citation | Fehniger TA, et al. (2001) Fatal leukemia in interleukin-15 transgenic mice. Blood Cells Mol Dis 27(1):223-30 |
| abstractText | ABSTRACT The role of inflammation in the early genesis of certain malignancies has recently been appreciated. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by multiple posttranscriptional mechanisms, suggesting that inappropriate expression of IL-15 may be detrimental to the host. We recently engineered a transgenic mouse in which the normal posttranscriptional control of IL-15 is eliminated, thereby overexpressing the murine IL-15 protein. IL-15 transgenic mice have early expansions in NK and CD8(+) T lymphocytes and later develop fatal lymphocytic leukemia with a T-NK phenotype. This article recapitulates the phenotype of these IL-15 transgenic mice and discusses the utility of this model as a tool to further our understanding of leukemogenesis. Copyright 2001 Academic Press. |
