| First Author | Zhang Y | Year | 2015 |
| Journal | Exp Neurol | Volume | 266 |
| Pages | 68-73 | PubMed ID | 25681574 |
| Mgi Jnum | J:219870 | Mgi Id | MGI:5629889 |
| Doi | 10.1016/j.expneurol.2015.02.006 | Citation | Zhang Y, et al. (2015) Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination. Exp Neurol 266:68-73 |
| abstractText | Blocking LINGO-1 has been shown to enhance remyelination in the rat lysolecithin-induced focal spinal cord demyelination model. We used transcranial magnetic motor-evoked potentials (tcMMEPs) to assess the effect of blocking LINGO-1 on recovery of axonal function in a mouse lysolecithin model at 1, 2 and 4weeks after injury. The role of LINGO-1 was assessed using LINGO-1 knockout (KO) mice and in wild-type mice after intraperitoneal administration of anti-LINGO-1 antagonist monoclonal antibody (mAb3B5). Response rates (at 2 and 4weeks) and amplitudes (at 4weeks) were significantly increased in LINGO-1 KO and mAb3B5-treated mice compared with matched controls. The latency of potentials at 4weeks was significantly shorter in mAb3B5-treated mice compared with controls. Lesion areas in LINGO-1 KO and mAb3B5-treated mice were reduced significantly compared with matched controls. The number of remyelinated axons within the lesions was increased and the G-ratios of the axons were decreased in both LINGO-1 KO and mAb3B5-treated mice compared with matched controls. These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1. |
