| First Author | Assumpção ALFV | Year | 2021 |
| Journal | Development | Volume | 148 |
| Issue | 7 | PubMed ID | 33766932 |
| Mgi Jnum | J:305433 | Mgi Id | MGI:6710302 |
| Doi | 10.1242/dev.197319 | Citation | Assumpcao ALFV, et al. (2021) A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development. Development 148(7):dev197319 |
| abstractText | Yin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte development and stem cell self-renewal. YY1 mediates stable PcG-dependent transcriptional repression via recruitment of PcG proteins that result in histone modifications. Many questions remain unanswered regarding how cell- and tissue-specificity is achieved by PcG proteins. Here, we demonstrate that a conditional knockout of Yy1 in the hematopoietic system results in an early T cell developmental blockage at the double negative (DN) 1 stage with reduced Notch1 signaling. There is a lineage-specific requirement for YY1 PcG function. YY1 PcG domain is required for T and B cell development but not necessary for myeloid cells. YY1 functions in early T cell development are multicomponent and involve both PcG-dependent and -independent regulations. Although YY1 promotes early T cell survival through its PcG function, its function to promote the DN1-to-DN2 transition and Notch1 expression and signaling is independent of its PcG function. Our results reveal how a ubiquitously expressed PcG protein mediates lineage-specific and context-specific functions to control early T cell development. |
