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Allele : Smad4<tm1.1Rob> SMAD family member 4; targeted mutation 1.1, Elizabeth J Robertson

Primary Identifier	MGI:3624263	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Smad4
Transmission	Germline	Strain of Origin	129S/SvEv-Gpi1<c>
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1 was removed via transient cre expression in ES cells. Western blot analysis shows that the predominant wild-type protein was absent in mutant ES cells.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
Smad4<N>,
Smad4<RobN>,
Smad4<RobN>,
Smad4<->,
Smad4<->,
Smad4<N>

earliestPublication:
Chu GC, et al. (2004) Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131(15):3501-12

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

11 Publication categories

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